Liver s4 generally refers to the left inner lobe of the liver. Transient enhancement in the arterial phase of the left inner lobe of the liver may be a sign of hepatocellular carcinoma. Hepatocellular carcinoma may be caused by cirrhosis, metastasis of cancer cells from other organs, and hepatitis virus. Since primary hepatocellular carcinoma mainly relies on hepatic artery for blood supply, rapid intensification will occur in the arterial phase, which may lead to the symptom of transient intensification. Patients should pay attention to rest, strictly prohibit alcohol and unnecessary drugs, patients with hepatitis B or hepatitis C should pay attention to personal hygiene, pay attention to the prevention and treatment of hepatitis B and hepatitis C. Family members should give psychological support to patients to reduce their bad emotions. In addition, it is recommended that patients with arterial phase transient intensification in the left inner lobe of the liver should go to the hospital in time and follow the doctor’s instructions for treatment to avoid delaying their condition.