The lack of menstrual flow in adolescent girls is considered to be related to the underdeveloped function of the reproductive endocrine axis and endocrine disorders, etc. Treatment should be based on the etiology of the disease and should be treated with progestational hormone preparations or short-acting contraceptives and other medications. 1. Reproductive endocrine axis function is not yet fully developed: since the reproductive axis function is gradually developing and maturing after girls enter puberty, some girls may experience clinical symptoms such as dribbling menstruation and disorders, which do not require any special treatment, and can return to the normal pattern after the function matures, or if necessary, the menstrual cycle can be adjusted by using progesterone preparation as prescribed by the doctor. 2. Endocrine disorders: (1) mental stress: if the girl is stressed, it is easy to cause endocrine disorders, at this time, parents should be appropriate to enlighten the child, maintain a happy mood, appropriate outdoor activities to relax, but also pay attention to the regularity of work and rest. (2) Polycystic ovary syndrome: due to the high level of androgen in girls, which in turn affects the normal function of the ovaries, leading to irregular ovulation or no ovulation and dribbling of menstruation, amenorrhea and other manifestations, at this time you can comply with the doctor’s instructions to use short-acting contraceptives to reduce the androgen or the use of progestational hormone agents to adjust the cycle, such as drospirenone ethinyl estradiol tablets, dieldroxyprogesterone, and so on. For adolescent girls with irregular menstruation, it is recommended to go to a regular hospital in time to improve ultrasound, sex hormones and other related examinations, to clarify the cause of the disease under the guidance of the doctor targeted treatment. The use of the above drugs should be strictly in accordance with medical advice.