Patients who have a cold and become feverish at night are commonly seen in cases where the inflammatory response in the airways is strong and the inflammation is not under control. Cold is the abbreviation of acute upper respiratory tract infection, which is usually caused by a decrease in immunity and infection by viruses, bacteria and other pathogens, which leads to changes in the mucous membrane of the upper respiratory tract with congestion, edema and exudation of inflammatory secretions. The patient’s inflammatory response is very strong and can lead to fluctuations in body temperature, resulting in fever. As the inflammatory response persists and is not controlled, it can easily lead to fever manifestations by the end of the day. Symptomatic and etiologic treatment should be administered promptly to relieve the symptoms, antipyretics can be used, and antipathogenic therapy should be given.