Hands and feet peeling can be treated by oral medication, topical medication, but due to more causes of hands and feet peeling, such as: eczema, ringworm, palmoplantar pustulosis, etc., the specific medication also needs to be selected according to the cause of the disease. 1. Eczema: you can choose to use zinc oxide paste, hydrocortisone cream, dexamethasone cream, etc., or oral loratadine tablets, cetirizine and other drugs for treatment under the guidance of a professional physician. 2. Tinea pedis: you can use topical compound benzoic acid ointment, ketoconazole cream, terbinafine cream, etc., oral itraconazole capsules, terbinafine tablets and other drugs for treatment. 3 palmoplantar pustulosis: you need to choose to use halometasone, fluticasone propionate, capotriol ointment, etc., oral methotrexate tablets, Avicenna, etc. under the guidance of a professional physician. Causes of peeling hands and feet more causes, when the symptoms of discomfort, should go to the hospital dermatology examination and diagnosis in a timely manner, under the guidance of a professional doctor for targeted treatment. Drugs need to be used in accordance with medical advice.