The causes of waking up with chest pain at night mainly include the following: the first cause is considered to be caused by diseases of the body’s cardiovascular system. Mostly due to the usual exertional angina, as well as myocardial ischemia and other underlying cardiac diseases, coupled with recent exertion or emotional excitement, which in turn causes an angina attack. The angina attack is usually obvious at night, so you need to go to the cardiology department of the hospital and have an electrocardiogram and cardiac ultrasound examination to clarify. At the same time, you need to take drugs to nourish the heart muscle and improve the blood supply to treat the symptoms. The second cause is due to respiratory diseases, including ruptured pulmonary alveoli and spontaneous pneumothorax. Due to the rupture of pulmonary alveoli, or spontaneous pneumothorax, the respiratory system of the body is affected, which in turn causes chest suffocation and pain. X-ray examination is needed to clarify. The third cause is due to intercostal nerve pain. Intercostal nerve pain is usually obvious at night and at rest, and can be significantly relieved by taking nerve-nourishing drugs.