The response to chemotherapy for colon cancer varies from person to person, some people have greater response to chemotherapy, some people have less response to chemotherapy, and some patients even have no response at all. If the pathology of colon cancer suggests lymph node metastasis or tumor is large and invades into the plasma layer, chemotherapy is usually needed. There are many chemotherapy regimens, including FOLFOX regimen, XELOX regimen, and many second-line regimens, and most patients have chemotherapy reactions. The most common chemotherapy reaction is myelosuppression, which will lead to lower white blood cells and lower granulocytes, as well as gastrointestinal reactions, many patients will experience nausea, loss of appetite, and in severe cases, vomiting, or even diarrhea.