Heparin can be continued with mildly elevated transaminases, and discontinuation of heparin is recommended for transaminases that are too high. Heparin belongs to anticoagulant drugs and can be used to treat thrombotic diseases. Some pregnant women apply heparin for fertility preservation therapy and need to use it for a long period of time, and prolonged use of heparin may lead to elevated transaminases. For these patients who cause mild liver abnormalities, liver-protecting drugs such as diammonium glycyrrhizinate enteric capsule and compound glycyrrhizin can be used concurrently with heparin, and liver function can be rechecked regularly. High transaminases indicate a greater degree of liver damage, and it is generally recommended that heparin be discontinued, and other anticoagulants with less impact on liver function can be substituted. In addition, heparin is commonly used in the prevention and treatment of thrombotic diseases, so it should not be discontinued on its own, and it is recommended to consult a doctor in time and follow the advice of the clinician.