The treatment principle of urine protein (++): First, if it has been diagnosed as caused by diabetic nephropathy, active glucose-lowering treatment is needed, and when blood sugar is controlled within the standard range, urine protein can also be reduced, which can be combined with the application of urine-lowering protein drugs, such as ACEI or ARB class, the most commonly applied drugs clinically are valsartan, olmesartanate, and benazepril class; Second, if it is caused by other secondary diseases, such as Myeloma tumor, lupus, the primary disease needs to be treated actively, especially the urine protein (++) caused by lupus, it is recommended to perform further renal aspiration biopsy to clarify the indicators of lupus activity, and if necessary, hormone shock therapy needs to be applied, such as inactive stage does not need shock therapy, but lifelong anti-immune therapy may be required.