Direct bilirubin 8.5μmol/L mostly indicates abnormality. The normal reference value of direct bilirubin is 0-6.8 μmol/L. Direct bilirubin 8.5 μmol/L suggests that the direct bilirubin is mildly elevated, which is related to factors such as diet, diseases and drugs. 1. Dietary reasons: the increase of direct bilirubin value caused by dietary factors is mostly mild, and the value is more than three times of the normal value, such as fatigue, staying up late, drinking alcohol, greasy food and so on. 2. Disease causes: Disease causes a significant increase in the value of direct bilirubin, more than three times the normal value, but can also be less than three times the normal value. If it is more than 10 times of the normal value, it suggests that the disease is progressing fast and requires timely medical treatment. Such as hepatitis, cholecystitis, hepatobiliary tumors. 3. Drugs: such as anti-tuberculosis rifampicin, isoniazid, etc.; such as antipyretic ibuprofen, indomethacin, etc.; such as chemotherapeutic drugs such as vincristine, methotrexate, etc., can cause liver damage, resulting in abnormalities in liver function indicators, including bilirubin. Direct bilirubin of 8.5μmol/L may also be caused by genetic factors, etc. It is recommended that the doctor analyze the specific causes and determine the condition in the light of the individual’s situation.