Roxithromycin and Levofloxacin can be used together, but only under the supervision of a physician. Roxithromycin is a macrolide antibiotic drug, while levofloxacin is a quinolone antibiotic drug, both drugs have antibacterial effect, can be used to treat infectious lesions caused by drug-sensitive pathogens. There is no contraindication between Roxithromycin and Levofloxacin, so in the presence of some serious infections or more complex infectious lesions, the drug can be used in combination treatment. The main adverse reactions caused by erythromycin are abdominal pain, diarrhea, nausea and vomiting; the most common adverse reactions caused by levofloxacin are insomnia, headache, nausea, diarrhea and so on. Roxithromycin must be contraindicated in people who are allergic to roxithromycin or other macrolides. While pregnant women, lactating women, people under 18 years of age and those who are allergic to levofloxacin are contraindicated for levofloxacin. During the use of Roxithromycin it is important to take care of regular liver function tests and the drug needs to be taken on an empty stomach with water. Individuals using levofloxacin who experience serious adverse drug reactions should inform their physician for disposition. Whether the drug is used alone or in combination, the drug should be used in strict compliance with the doctor’s instructions and should never be abused.