Duodenal bulbous ulcer still hurts after 6 weeks of medication, including standardized medication, dietary adjustments, continuing to take medication or changing medication, endoscopic or surgical treatment. 1. Standardized medication: not taking medication on time and adjusting the dosage of medication on one’s own can lead to the symptom of pain even after 6 weeks of taking medication; in such cases, one should standardize the medication and should not stop taking the medication or reduce the dosage on one’s own. 2. Adjust the diet: if you do not follow a healthy diet in the process of taking medication, it can also cause duodenal ulcer to still hurt after 6 weeks of taking medication; in this case, you should maintain a light, easy-to-digest diet, eat small meals, avoid overeating and drinking coffee, strong tea, alcohol and so on. 3. Continue to take medication or change medication: For patients with large ulcers and Helicobacter pylori infection, they need to take medication for a longer period of time to get better, in this case, it is recommended to continue to take medication; if the current medication can not relieve the patient’s symptoms, it is recommended to change the medication under the guidance of the doctor. 4. Endoscopic or surgical treatment: After the doctor’s judgment to determine the internal medicine treatment is ineffective need to consider endoscopic treatment or surgical treatment. Patients with duodenal bulbous ulcers that still hurt after 6 weeks of medication should actively cooperate with their doctors for treatment, and if their symptoms do not improve, it is recommended that they go to the hospital and take medication under the guidance of their doctors.