The treatment of lumbar spondylolisthesis mainly includes general treatment, drug treatment, surgical treatment and so on. 1. General treatment: when the fifth lumbar vertebra slips, there is no obvious clinical symptoms, not accompanied by lumbar pain, numbness of the legs, feasible conservative treatment, you can wear a lumbar circumference or support, pay attention to rest, reduce the weight-bearing activities, exercise the muscles of the lower back, and so on. 2. Medication: When lumbar spondylolysis leads to local instability and pain, some anti-inflammatory and analgesic ointment can be used topically, such as Yunnan Baiyao ointment, or non-steroidal anti-inflammatory drugs (such as Celecoxib) can be taken to relieve pain. 3. Surgical treatment: for the fifth lumbar spondylolisthesis is serious, when there is spinal stenosis or nerve damage, or when conservative treatment is ineffective, surgical treatment should be taken, including lumbar spine minimally invasive surgery, implantation of internal fixation, and so on. When the fifth lumbar vertebral slip occurs, it should be standardized treatment under the guidance of the doctor, so as not to delay the condition. In addition the above drugs should also be used under the guidance of a doctor.