The clinical significance of proteinuria +- is the presence of a small amount of albumin in the urine. Protein should not be present in the urine of a normal person, and when protein is present in the urine, no matter how much, it means there is kidney damage. Urine protein +-, suggests that the amount of protein in the urine is relatively small, often less than 1 gram. This condition is most often seen in mild kidney disease or early stages of certain kidney diseases, such as early chronic glomerulonephritis, diabetic nephropathy or occult nephritis, which are relatively mild diseases, and may also be seen in IgA nephropathy, etc. In this case, you need to check 24h urine protein quantification, as well as creatinine, urea and renal ultrasound to assess the kidney condition. For treatment, Bering capsules can be applied to protect the kidneys, as well as ACEI/ARB drugs to reduce urine protein, commonly used drugs such as Irbesartan and Benazepril. Urine routine and urine protein quantification should be reviewed every 1-3 months to assess protein leakage. If the disease worsens, kidney puncture can be examined to clarify the pathology and further adjust the treatment plan to prevent kidney damage.