Here is a brief and clear explanation of the problem: i. If it is a first case, I advocate just treating with olanzapine. That night, start with olanzapine 10 mg, and if there is no abnormal reaction, from the next day onwards, use olanzapine 20 mg every night. On the third day, 5 mg in the morning and 20 mg at night. Observe for 2-4 weeks, and if the symptoms have not disappeared, increase to 30 mg, either 10 mg in the morning and 20 mg at night. As for taking the medication at once or splitting it in the morning and evening, and how much to take each time, you can choose according to the specific reaction and on your own. At the same time, it is necessary to take Benadryl (1-2 tablets 2-3 times a day) to prevent side effects (Note). If after taking the drug appears to be unable to sit still (the patient himself feels restless, fidgety, etc., see 3; generally speaking, as long as the benzhexol is sufficient, there will be no sitting still side effects), you can temporarily add 2 capsules of benadryl, usually can be relieved within 15 minutes, there is no need to panic. Some patients with lorazepam or other tranquilizers, it is also possible to solve the problem. At this time, it is reasonable to increase the dose of benzhexol, it is possible to fundamentally prevent the emergence of such side effects. Second, if it is a case of repeated application of risperidone, aripiprazole, quetiapine and other antipsychotics, and still did not solve the problem, I suggest to stop the original drug at once and switch to olanzapine treatment. Hopefully, the dose will be increased to 25 or 30 mg in one step. Of course, it is possible to add olanzapine on top of the original medication. However, I do not advocate the latter approach, leaving the drugs such as risperidone, aripiprazole and quetiapine there, which I think has little benefit and vainly increases the side effects. Third, when olanzapine is applied for treatment, there are very few side effects. However, some reactions inevitably occur in individual cases, such as: drowsiness, dull face, slow movement, inability to sit still, increased appetite, and in a very small number of patients, after taking the drug, two eyes may be turned upward, called motility crisis. Some patients develop obsessive-compulsive symptoms, and it is not necessary to pay attention to them if they are mild. If it is more serious and affects your life, you can take fluoxetine 40 mg every morning. It will disappear on its own after the drug is later reduced and stopped. The advantages of olanzapine are: 1, the efficacy is significantly better than risperidone, quetiapine, ziprasidone, or aripiprazole, it can be said that not a class; 2, extra-cone side effects are significantly less than risperidone or ziprasidone; although there is the possibility of sedation can not be, but in a split dose, or temporary take the drug, can be successfully resolved; 3, is currently the only antipsychotic drugs do not affect the function of the heart; 4, although also There may be induced compulsion, but less than clozapine or risperidone; 5, weight gain may be greater, but can be resolved through dietary control of the problem; can also take metformin, one tablet per meal, may help. 6, there are already national products, 10 mg 20 yuan per tablet; regardless of efficacy or side effects, and imported goods, the exact same. 5, if olanzapine alone, still failed to as desired. Then you can combine those antipsychotics that are not exactly the same pharmacological mechanism on top of olanzapine 20-30 mg.