High total bilirubin also needs to check liver enzymes, hepatitis markers, abdominal ultrasound and other tests, which need to be examined in conjunction with the patient’s condition. Total bilirubin is the sum of indirect bilirubin and direct bilirubin, and the normal reference value is 3.4-17.1 μmol/L. Causes of elevated total bilirubin include physiological causes such as prolonged alcohol intake, strenuous exercise, neonatal jaundice, etc.; and it is also commonly found in hepatitis, obstructive jaundice, cirrhosis of the liver, pathological jaundice of the newborn, cholelithiasis, cancer of the head of the pancreas and hemolytic jaundice. Therefore, elevated total bilirubin also needs to check direct bilirubin and indirect bilirubin levels, liver enzymes, hepatitis markers, abdominal ultrasound, CT and other tests, and according to the patient’s specific symptoms, signs, and the underlying disease, the further examination items are different. It is recommended that patients seek medical treatment in a timely manner and develop the next examination plan after comprehensively analyzing their symptoms and signs.