Pituitary adenomas that do not secrete the prohormones and trophic hormones that cause clinical symptoms are called non-functioning pituitary adenomas. They account for approximately 30% of all pituitary adenomas. It has been found that most non-functioning pituitary adenomas do secrete pituitary hormones, mostly gonadotropins (FSH and LH). Since these tumors do not have clinical symptoms caused by hormone excess and have an insidious course, they are not brought to the attention of patients until the tumor grows and causes visual impairment. Treatment options for non-functioning pituitary adenomas Surgery: This is the most fundamental and relatively effective treatment for non-functioning pituitary adenomas. The tumor is usually removed using a transsphenoidal approach (endoscopic transsphenoidal surgery is preferable to conventional surgical microscopic transsphenoidal surgery). This procedure allows for complete removal of the tumor and some restoration of pituitary function. For tumors with irregular and aggressive growth, the aim of surgery is to reduce the size of the tumor and complete removal of the tumor is not necessary or possible. The efficacy of surgery and the incidence of surgical complications depend on the growth pattern of the tumor, the experience and expertise of the surgeon. A thorough post-operative endocrinological evaluation is required and timely hormone replacement therapy if necessary. Radiotherapy: It is not usually the treatment of choice for non-functioning pituitary tumors. Studies over the years have shown that radiotherapy is difficult to control the growth of this type of tumor and instead often leads to pituitary hormone deficiency. Radiotherapy is often used as an adjuvant treatment for postoperative residual tumors; for postoperative residual tumors, only close observation is required, and immediate radiotherapy is usually not necessary. During the postoperative observation process (six months, one year, one year…), if the tumor shows signs of regrowth, the patient’s characteristics, the size, location and invasiveness of the tumor will determine whether to re-surgery proposed or receive radiotherapy. Drug therapy: There are no effective drugs for the treatment of non-functioning pituitary adenoma.