Skin allergy to drugs have the following manifestations: 1, the skin will appear erythema, rash, itching, ulceration, large areas of redness and swelling, and sometimes there will be a large area of skin loss, ulceration, necrosis and so on, which should be promptly go to the hospital for symptomatic treatment. 2, the skin allergy can cause systemic toxicity after the drug can be absorbed through the skin and enter the bloodstream, resulting in headache, dizziness, swelling, numbness of mouth and tongue, as well as liver and kidney damage, there will be a significant increase in transaminases, there will also be blood urine, proteinuria and other kidney damage. Swelling, numbness of the mouth and tongue, as well as liver and kidney damage, there will be a significant increase in aminotransferases, there will be hematuria, proteinuria and other renal damage, skin allergies can also cause tachycardia, arrhythmia, as well as abdominal pain, diarrhea, nausea and other uncomfortable symptoms.