Sweating in the middle of the night may be caused by hyperthyroidism, tuberculosis and other diseases, for female patients also need to consider perimenopausal syndrome, patients can take medication, surgical treatment. 1. Hyperthyroidism: hyperthyroidism patients will appear sweating, fatigue, irritability and other symptoms, patients can follow the doctor’s instructions oral methylthiouracil, propylthiouracil and other anti-thyroid drugs. If necessary, thyroidectomy and other surgical methods can be taken for treatment. 2. Tuberculosis: Tuberculosis patients will have low fever, night sweats, emaciation and other symptoms, patients can follow the doctor’s instructions oral isoniazid tablets, rifampicin tablets, pyrazinamide tablets and other anti-tuberculosis drugs for treatment. If the effect of drug treatment is not obvious and the condition is serious, surgery can also be adopted. 3. Perimenopausal syndrome: Patients with perimenopausal syndrome may have symptoms such as hot flashes, sweating, menstrual changes, etc. They can be treated with estrogens and progestins such as estradiol valerate tablets and dydrogesterone tablets according to the doctor’s instructions. Patients can also be treated with estrogen-progestin combination preparations such as estradiol dydrogesterone tablets and estradiol dydrogesterone tablets. Patients should seek medical attention when they experience symptoms of sweating in the middle of the night. Patients should follow the doctor’s instructions to use medication, avoid blind use of drugs.