Atrophic gastropathy can be cured, but failure to treat it aggressively may also cause further progression of the condition. Atrophic gastropathy generally refers to atrophic gastritis, the cause of this disease, the more common is Helicobacter pylori infection, Helicobacter pylori infection will lead to chronic non-atrophic gastritis, gradually develop into atrophic gastritis, there will also be intestinal chemotaxis and heterotrophic hyperplasia. Most patients with H. pylori can be eradicated through quadruple medication, which is a proton pump inhibitor such as omeprazole + a bismuth agent such as colloidal bismuth + two antibiotics such as amoxicillin and clarithromycin. After the eradication of Helicobacter pylori, it can improve the gastric mucosal atrophy to a certain extent, in addition to preventing the occurrence and development of intestinal metaplasia, and the symptoms of gastric mucosal atrophy in some patients are reversible, but intestinal metaplasia is difficult to be reversed. Suffering from atrophic gastropathy should be actively follow the doctor’s instructions for treatment, in order to reduce the adverse effects of the disease, the above drugs should be used under the guidance of a doctor.