Irbesartan hydrochlorothiazide long-term use hazards include gastrointestinal discomfort symptoms, hypokalemia, hepatic and renal impairment, and mental irritation symptoms. 1. Gastrointestinal discomfort symptoms: long-term use of the drug may cause abdominal pain, diarrhea, heartburn, dyspepsia, loss of appetite and other gastrointestinal symptoms. Hypertensive patients with gastrointestinal disorders can use the drug after meals to reduce the irritation of the drug on the gastrointestinal mucosa. 2. Hypokalemia: Hydrochlorothiazide, as a diuretic, reduces blood potassium levels; Irbesartan can selectively block AT1 subtype receptors to exert antihypertensive effects, while attenuating hydrochlorothiazide-induced reduction in blood potassium. If the patient is sensitive to diuretic components, low blood potassium may result during long-term use. 3. Impairment of liver and kidney function: drug metabolism passes through the liver and kidney, long-term use of the drug may affect the detoxification function of the liver and the filtration function of the kidney, especially in elderly patients, it is recommended that the liver and kidney function should be reviewed regularly. 4. Mental stimulation symptoms: such as excessive anxiety, nervousness or even depression, and decreased sleep quality due to mental symptoms. Long-term use of the drug will cause financial burden and mental stress to the patient, correct understanding of hypertension and antihypertensive drugs, treatment period should not have excessive psychological pressure. It is recommended to take the drug under the guidance of a doctor, it is contraindicated for those who are allergic to the components of the drug, those with severe liver and kidney function damage, patients with intractable hypokalemia or hypercalcemia, and patients with insufficient blood volume.