Children usually need to take cephalosporin at intervals of 6~8 hours, and some of them may need intervals of 10~12 hours. Cephalosporin is more commonly used antibiotics, such as cefaclor, cefprozil, etc., two oral intervals need to be decided according to the metabolic characteristics of cephalosporin, for example, the half-life of cefaclor is 30-60 minutes, the two intervals need to be 8 hours; cefprozil’s half-life of 1-2 hours, the two intervals for 10-12 hours. In the oral cephalosporin treatment of disease, should strictly comply with the medical prescription of medication, during the use of medication, we should closely observe the child whether there is a rash, diarrhea and other adverse reactions, once appeared, to immediately stop oral and take the child to the hospital pediatrics, if the child has an allergic reaction to the cephalosporin antibiotics, it is not appropriate to oral cephalosporin drugs.