Whether a thyroid nodule 6.1×6.3 mm is serious or not needs to be judged in conjunction with the location and thyroid function. If there are no obvious symptoms and thyroid function is normal, it is usually not serious. Benign thyroid nodules include multinodular goiter, Hashimoto’s thyroiditis and cysts. The vast majority of malignant nodules are thyroid cancer, and a few are primary thyroid lymphoma or metastatic thyroid cancer (breast cancer, kidney cancer, etc.). Thyroid nodule 6.1 x 6.3 mm, the nodule’s size is small, it may be benign lesion, if there is no obvious symptom, you need to check the thyroid function regularly in endocrinology department, if the thyroid function is normal, then there is no need for treatment. If the thyroid function is abnormal, appropriate medication should be given according to the thyroid function, and thyroid ultrasound should be checked regularly. If the thyroid nodule continues to enlarge and there are symptoms of compression of the trachea and esophagus, such as dyspnea and dysphagia, then surgical treatment is required. If necessary, thyroid puncture examination is needed, and according to the results of the examination, appropriate treatment will be done. In conclusion, it is recommended to consult an endocrinologist as soon as possible for thyroid nodules.