Periportal hepatitis, or cancer cells invading the liver surface and adjacent peritoneum, may become rough due to fibrinous exudate and cause friction sounds. Then, how to diagnose friction sounds in liver area? Here is the explanation for you. How to diagnose hepatic fricative sound 1.Liver function and hepatitis related indexes: Since about 80% of hepatocellular carcinoma have liver disease background such as cirrhosis and hepatitis, so if abnormal liver function and positive hepatitis B and C markers are detected, it indicates the basis of liver disease of hepatocellular carcinoma, meanwhile, liver function test can estimate the surgical tolerance, which is helpful to assist in diagnosis and treatment and prognosis estimation. 2.Immune indexes: The tests can help to understand the early stage of disease and prognosis, and also help to reflect the treatment effect, such as tuberculin skin test (OT test), lymphocyte transformation test, natural killer cells (NK), macrophage viability, T cell subpopulation measurement, etc. 3.Hepatocellular carcinoma markers: There are dozens of serum hepatocellular carcinoma markers reported in the literature, among which the most important one is alpha-fetoprotein. 4.alpha-fetoprotein (AFP) has high clinical value in the diagnosis of hepatocellular carcinoma, and is the diagnostic method second only to pathological examination in terms of specificity among various diagnostic methods, and about 60%-70P of patients with hepatocellular carcinoma in China are higher than normal values. The diagnosis of hepatocellular carcinoma can be made by using AFP test, if AFP ≥ 400ng/ml for 1 month or ≥ 200ng/ml for 2 months, without evidence of active hepatitis and excluding pregnancy and germinal gland embryonal carcinoma, AFP is currently the best early diagnosis method, and this diagnosis can be made 6-12 months earlier than the symptoms of hepatocellular carcinoma. In addition, AFP can also be used as an indicator of the efficacy of treatment.