After the onset of cerebral infarction for more than 6 hours, the brain cell function may cause irreversible damage, and even if thrombolysis is performed, the brain cell function cannot be restored after the thrombus is dissolved, which may cause reperfusion injury and increase the risk of cerebral hemorrhage. Therefore, the time window of thrombolytic therapy for cerebral infarction patients is within 6 hours, and if the onset is more than 6 hours, neuroprotective and blood circulation improvement therapy should be applied, and oral aspirin and clopidogrel antiplatelet therapy should be actively administered. If the onset time is within 4.5 hours, clinical application of alteplase for intravenous thrombolysis, and more than 4.5 hours, application of urokinase thrombolysis within 6 hours, thrombolysis may rapidly restore cerebral blood flow and improve brain tissue metabolism, which can save only the ischemic semidark zone tissue with functional changes, thus reducing the lethality and disability of patients.