Closed-cell pimples are a manifestation of acne, and are associated with poor lifestyle and dietary habits, sebaceous gland secretion, and discharge disorders, and should be properly treated with medication, physical therapy, and maintaining a healthy lifestyle. 1. Drug treatment: always long closed mouth acne should pay attention to the correct treatment, if the treatment is not complete will lead to recurrence of the disease, mainly the use of retinoic acid drugs, such as retinoic acid cream, tazarotene, adapalene, if there is inflammation can be used benzoyl peroxide and azelaic acid. The drugs should be used according to the doctor’s prescription. 2. Physical therapy: Combined with photodynamic therapy and red and blue light to inhibit the secretion of sebaceous glands and kill Propionibacterium acnes more effectively, this can prevent recurrent acne. 3. Maintain a healthy lifestyle: the recurrence of closed mouth acne also has a lot to do with lifestyle, you should eat a reasonable diet, eat more fresh fruits and vegetables, do not eat high fat, high sugar food. Usually do not squeeze the acne with your hands, keep the skin clean and hygienic, avoid staying up late, keep a good mood, avoid anxiety, depression, tension and so on. Always long closed mouth acne may also have other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, give targeted treatment or standardized treatment.