Pioglitazone metformin can be taken once a day, need to be decided according to the patient’s blood sugar level, if the blood sugar is only mildly elevated, can be taken once a day. If the elevation of blood sugar is too large, it can be taken twice a day, the specific medication should follow the doctor’s instructions. Pioglitazone metformin is a compound preparation of hypoglycemic drugs, can reduce fasting blood sugar and postprandial blood sugar. And it is not easy to produce hypoglycemia, especially for patients with combined insulin resistance. Pioglitazone metformin can be taken once or twice a day. For only mildly elevated blood sugar, it can be taken orally once a day. If the blood glucose still does not reach the standard once a day orally, you can increase the dosage to twice a day, and if it still does not reach the standard, then consider adding other hypoglycemic drugs combination therapy. Pioglitazone Metformin should be used wisely under the guidance of a doctor to avoid adverse reactions.