High unsaturated iron binding capacity may be associated with iron deficiency anemia, severe heavy metal poisoning, cirrhosis of the liver and other diseases. 1. Iron deficiency anemia: Iron deficiency anemia reduces the amount of iron in the body, resulting in insufficient binding capacity of transferrin, which will lead to high unsaturated iron binding capacity. 2. Severe heavy metal poisoning: common heavy metal poisoning includes mercury poisoning, lead poisoning, etc. Severe heavy metal can destroy protein structure, inhibit enzyme activity, and interfere with normal cellular metabolism, which will lead to iron metabolism abnormality, resulting in high unsaturated iron binding capacity. 3. Cirrhosis: In cirrhosis, the decline of liver function will lead to iron metabolism disorder, resulting in diffuse iron deposition in the liver, which will also lead to high unsaturated iron binding capacity. Therefore, if unsaturated iron binding capacity is found to be high, it is recommended that a comprehensive judgment be made under the guidance of a doctor to find out the specific cause of the disease and carry out subsequent treatment.