High-throughput genetic sequencing prenatal screening is not a required program. High-throughput genetic sequencing prenatal screening, also known as non-invasive prenatal DNA testing, is mainly used to detect trisomy problems on the 18th, 21st and 13th pairs of fetal chromosomes, such as trisomy 21, i.e., Down’s syndrome, etc., and the accuracy of screening for Down’s syndrome is generally up to 95%. High-throughput genetic sequencing prenatal screening is based on the principle of testing by drawing blood from a pregnant woman and extracting free DNA fragments of the fetus from the blood sample to assess the presence of common chromosomal problems in the fetus. Indications for the need of high-throughput gene sequencing prenatal screening include pregnant women with Down’s syndrome screening results suggesting high and critical risk, pregnant women with a history of previous fetal malformations or a history of poor pregnancy and delivery, etc. Eligible pregnant women should undergo screening to better understand the development of the fetus. Pregnant women who are eligible for prenatal screening by high-throughput gene sequencing should undergo the test as prescribed by their doctor.