You can’t drink alcohol while taking painkillers. Painkillers, such as ibuprofen, nimesulide and diclofenac sodium, are non-steroidal anti-inflammatory painkillers that have certain side effects. Some of these medications may cause digestive symptoms such as acid reflux, heartburn, and epigastric discomfort. After taking painkillers orally, drinking alcohol may aggravate the symptoms, because alcohol may also produce strong stimulation of the gastric mucosa, causing excessive secretion of gastric acid, thus aggravating the above symptoms, and in severe cases, may cause gastrointestinal bleeding or gastric perforation. In addition, painkillers may also affect the metabolism of alcohol, resulting in adverse reactions, such as may cause disulfiram-like reaction, the patient may appear flushing, increased heart rate, chest tightness, panic, and in severe cases, shock may occur. Therefore, it is not possible to drink alcohol during the taking of painkillers, and if the above symptoms occur when drinking alcohol during the taking of painkillers, you should go to the hospital for examination and treatment in a timely manner.