Epidural hormone closure therapy is a widely used clinical method for the treatment of lumbar disc herniation. It is safe, reliable, easy to operate, and certainly effective, and can be used for both acute and chronic onset. The epidural cavity is a potential gap located in the spinal canal, not only 31 pairs of spinal nerves pass through this cavity, but also there are abundant nerve fibers and their endings distributed on the surface of the dura mater and nerve root sheath, the inner surface of the posterior longitudinal ligament and the yellow ligament. Stimulation of a herniated disc or other pathological factors can cause aseptic inflammation of the epidural cavity, causing nerve endings to conduct impulses in response to stimulation and produce nociception. The injection of hormones and anesthetic drugs into the epidural cavity can improve blood circulation and eliminate inflammatory reactions such as congestion and edema, while inhibiting the excitability of nerve endings and blocking the vicious cycle of pain. In addition, reports have confirmed that injecting enough drugs at the time of closure can generate fluid pressure as the drug diffuses along the intervertebral foramen, causing the nerve root to peel off the herniated disc tissue and relieving the compression. It follows that successful epidural closure may release both the chemical irritation and mechanical compression that cause the clinical symptoms of lumbar disc herniation. Of course, for the more severe nerve root compression caused by huge herniation, it is difficult to receive good results with closure therapy because the stimulating and compressing factors that cause symptoms cannot be released.