Waking up with a sore throat may be caused by open-mouth breathing during sleep, but also does not exclude the pre-cold symptoms and pharyngitis and other causes, should be timely consultation to identify the cause of the disease. 1. Open-mouth breathing: due to sleep snoring, poor nasal ventilation, narrow oropharyngeal cavity, hypertrophy of the tongue, or the patient is fat, can not be moistened through the nasal cavity during sleep, and directly open-mouth breathing, resulting in pharyngeal mucosal dryness, waking up with a sore throat, dry and itchy symptoms. 2. Pre-cold: Most of them are caused by viral infections, which may also be due to coronavirus, parainfluenza virus, respiratory syncytial virus and so on. If you get cold at night or have a sudden change in climate, it may lead to waking up with a sore throat, runny nose, sneezing and other symptoms. 3. Pharyngitis: If there is dust, irritating gas, indoor too dry, smoke, etc. when you sleep at night, it may trigger pharyngitis, leading to dry, itchy, sore throat, difficulty in swallowing and other symptoms when the patient wakes up. There may be other reasons for waking up with a sore throat, and you should consult a doctor in time to clarify the specific cause and treat accordingly if necessary.