If melanin deposits in the neck are caused by sun exposure, no special treatment is needed. If it is caused by melanosis, Cushing’s syndrome and other diseases, we need to take medication and surgical treatment for the cause of the disease. 1. Sunlight exposure: because sunlight exposure will enhance tyrosinase activity, thus causing hyperpigmentation, generally no special treatment, but usually need to pay attention to the neck of the sun, you can insist on the use of whitening, lightening the role of melanin skin care products. 2. Melanosis: common symptoms include damaged skin pigmentation, dust-like skin debris attached to the surface. Patients need to follow the medical advice of local use of compound arbutin cream, hydroquinone cream and other drugs, inflammation is serious, it is necessary to follow the medical advice of the application of glucocorticosteroids, such as dexamethasone, hydrocortisone. For those with obvious hyperpigmentation, intravenous injection of vitamin C, sodium thiosulfate, compound sodium glycyrrhizinate and other drugs is required. 3. Cushing’s syndrome: typical symptoms include centripetal obesity, bone pain, and skin pigmentation. Patients need to follow the doctor’s instructions to apply cyproheptadine, bromocriptine and other neuromodulators, as well as metipranone, amiloride, bis(chlorophenyl)ethylene chloride and other cortisol synthesis inhibitors. For Cushing’s syndrome caused by pituitary adenomas, transsphenoidal sinusectomy is required; in the case of adrenal tumors, surgical procedures such as open adrenal tumor resection are required. If the neck melanin precipitation is diagnosed as a result of the disease, the patient needs to cooperate with the doctor to actively treat, so as not to delay the disease.