Burning sensation in the esophagus is usually caused by improper diet, esophagitis, gastrointestinal diseases or mental factors, as follows: 1. Improper diet. The burning sensation is usually caused by improper diet, esophagitis, gastrointestinal diseases or mental factors as follows: 1. It is an inflammation caused by bleeding and edema of the esophageal mucosa, and is commonly associated with reflux esophagitis due to acid reflux, accompanied by chest pain and nausea. 3, gastrointestinal diseases. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. Long-term mental tension, anxiety or emotional instability will stimulate the cerebral cortex to affect the secretion of gastric acid.