The side effects of head and neck radiotherapy mainly include skin reaction, radioactive oral mucositis and systemic reaction, etc. General treatment and medication can be selectively administered. 1. Skin reaction: radiotherapy may cause redness, dryness and other discomforts, at this time, we should avoid scratching and rubbing the relevant parts, avoiding applying skin care products and cosmetics on the relevant parts, and avoiding exposure to sunlight as well as hot and cold stimuli. 2. Radiation oral mucositis: increase the amount of drinking water, but should pay attention to the use of warm water; avoid eating spicy and stimulating food, avoid drinking alcohol; patients with localized ulcers should follow the instructions of the physician, and carry out the necessary medication (such as compound vitamin B solution, etc.). 3. Systemic reaction: radiotherapy can lead to headache, nausea, vomiting, fatigue and other systemic reactions, at this time, attention should be paid to the diet should be light, increase the intake of fruits and vegetables, drink more water in moderation, and ensure that rest at the same time, you can carry out a certain amount of exercise. After head and neck radiotherapy discomfort, it is recommended to inform the doctor in time, follow the doctor’s instructions for treatment.