Allergy in children is a systemic disease that can have different clinical manifestations in the child’s skin, respiratory system, and digestive system. For children with allergies, the first step is to identify the cause and to remove the cause, do allergen testing if necessary, avoid allergy principles if they can be identified, and treat the child according to the different clinical manifestations. If the child has skin symptoms, such as eczema and urticaria, the child should be given oral antihistamines, such as cetirizine and loratadine, and topical glycolic lotion and zinc oxide ointment, etc. If necessary, topical glucocorticoids should be used. If the child has respiratory symptoms, such as coughing and wheezing, nebulized inhalation and oral montelukast sodium, cetirizine, loratadine, etc. should also be given. In addition, parents need to be reminded that if the child’s allergy is more serious, a severe allergic reaction will occur and the child will have more serious symptoms in the respiratory system, digestive system, circulatory system and the nervous system. At this time, parents are advised to take their children to the hospital. The drug of choice for severe allergic reactions is epinephrine, which should be given as an intramuscular injection in the outer thigh.