The treatments for lung adenocarcinoma with multiple metastases and metastasis to the brain include chemotherapy, targeted therapy, immunotherapy, radiotherapy and so on. 1. Chemotherapy: drugs include carboplatin, cisplatin, paclitaxel, etc. Adenocarcinoma responds poorly to chemotherapy, and combined chemotherapy can alleviate patient’s symptoms, improve the quality of life and prolong the survival period. 2. Targeted therapy: drugs include gefitinib, erlotinib, afatinib, etc., which can selectively inhibit tumor growth at molecular level. 3. Immunotherapy: drugs such as pembrolizumab and atezolizumab are emerging treatments in recent years. 4. Radiotherapy: Lung cancer is sensitive to radiotherapy, which is usually combined with chemotherapy, and the treatment plan is different according to the stage of disease, treatment purpose and patient’s condition. Patients with multiple metastases of lung adenocarcinoma and metastasis to the brain need to consult doctor in time and take active and standardized treatment according to doctor’s advice.