Acute rash is a common disease in infants and young children characterized by high fever and rash, mostly occurring in spring and fall. Symptomatic supportive treatment is the mainstay, and medication can be prescribed if necessary. The main symptom of infantile rash is fever for 3 to 5 days, with body temperature as high as 39℃ or higher; the rash usually appears 12 to 24 hours after the fever subsides, and the rash is a red maculopapular rash distributed on the face and trunk, which can last for 3 to 4 days. Some children may have characteristic erythema of the soft palate; other symptoms include: eyelid edema, bulging fontanel, cough, and diarrhea. The disease is self-limiting, so no specific treatment is needed and most children have a good prognosis. It is important to note that when a child has a persistent temperature of ≥38.5°C, non-steroidal anti-inflammatory drugs such as acetaminophen and ibuprofen may be prescribed to reduce fever. All of the above drugs should be used under the guidance of the doctor, avoid self-medication. Daily attention should be paid to strengthen nursing care and avoid contact with other infants.