Penile infections may be bacterial infections or infections caused by viruses, fungi and other disease-causing microorganisms, all of which can be washed with povidone-iodine. And ofloxacin belongs to antibacterial drugs, effective for bacterial caused penile infection, for viruses, fungi and other microorganisms caused by penile infection is not effective. Iodophor belongs to the broad-spectrum bactericidal effect, not only for bacterial infection is effective, for fungi, protozoa and viruses have the role of killing, so in the clinic is mostly used for sterilization disinfectant. However, it is mainly used to disinfect the surface of the skin or mucous membranes, and has no effect on killing pathogenic microorganisms inside the infected foci. Ofloxacin gel belongs to the fluoroquinolone class of broad-spectrum antibacterial topical drugs, so for bacterial penile infections, can be cleaned and disinfected in iodine vapour, topical ofloxacin gel treatment, but for the protozoa, fungi, and viruses caused by penile infections is ineffective. Iodophor can act as an irritant to the mucous membranes when used, and a few patients are allergic to iodophor. The adverse effects of of ofloxacin gel are not known, and it is forbidden to use it for those who are allergic to fluoroquinolones. In summary, for bacterial penile infection can be povidone-iodine wash coated with ofloxacin gel, while for fungal, viral and other causes of penile infection can be povidone-iodine wash disinfection, the use of of ofloxacin gel is ineffective. The specific situation is recommended to go to the hospital, complete the examination to determine the cause of the disease, the drug under the guidance of a professional physician.