The accuracy of intraoperative frozen section of lung nodule is more than 90%, there is a certain possibility of false positive or false negative, after the operation, routine paraffin section for comprehensive judgment, to improve the accuracy. Intraoperative frozen section of lung nodules is a judgment made by pathologists on the morphology of tissue cells, which may be incomplete due to the complexity of human tissues and atypicality of disease lesions, which may have a certain impact on the accuracy of intraoperative frozen section. The main advantage of intraoperative frozen section is that it is easier to operate, and the result is faster. For patients who have undergone intraoperative frozen section, routine paraffin section is also needed to further clarify the diagnosis after operation, and immunohistochemistry can be used to clarify the diagnosis if necessary. Clinical diagnosis of a disease does not rely solely on a single test, but requires a complete set of related examinations, and the most accurate diagnostic results can be obtained from a comprehensive examination under the guidance of a doctor. If you have lung nodule disease, it is recommended to go to the hospital in time, and follow the doctor’s instructions for treatment.