Mycoplasma positive babies are usually considered to have mycoplasma infections, which often tend to adhere to the respiratory mucosa and cause damage to the respiratory mucosa resulting in increased airway secretions and increased reactivity causing clinical coughing and even asthma for a long time. Mycoplasma infections should be treated with azithromycin, generally treatment with cephalosporins or penicillins is not effective. Mycoplasma infections can be mild or severe, and mild infections that only manifest as a cough are usually treated with oral azithromycin for 2-3 weeks. If the mycoplasma infection is relatively serious, especially fever, shortness of breath, pulmonary imaging changes with pleural effusion, pleurisy or large lamellar changes, treatment takes relatively longer, and severe cases may also require intravenous azithromycin treatment, as well as symptomatic supportive treatment to stop coughing and dissolve phlegm.