The difference between Crohn’s disease and ulcerative colitis mainly lies in clinical symptoms, lesion sites, complications, endoscopic manifestations and pathologic examinations. 1. Clinical symptoms: Crohn’s disease mostly has no symptoms of mucopurulent blood stools and acute and severe symptoms, while ulcerative colitis mostly has the above symptoms. 2. Lesion site: Crohn’s disease occurs in the end of the ileum and adjacent parts of the colon; ulcerative colitis occurs in the colon, with the rectum and sigmoid colon. 3. Complications: Crohn’s disease can have the complication of intestinal stenosis, and ulcerative colitis can have the complication of toxic megacolon and colon cancer. 4. Endoscopic examination: Crohn’s disease nei’jing’x can have longitudinal ulcers, cobblestone-like changes, ulcerative colitis can be seen purulent secretions, intestinal mucosal erosion and ulceration. 5. Pathologic examination: Crohn’s disease is non-caseating granuloma, ulcerative colitis is crypt structure change. For the difference between Crohn’s disease and ulcerative colitis, it is recommended to consult a doctor for differentiation according to individual circumstances.