Clinical manifestations of membranoproliferative glomerulonephritis include massive proteinuria, hypoproteinemia, edema and so on. 1. Massive proteinuria: under normal physiological condition, glomerular filtration membrane has molecular barrier and charge barrier function, these barriers are impaired resulting in the increase of protein content in the original urine, when the protein content in the original urine is more than the reabsorption capacity of the renal tubule, the protein will be lost from the urine and massive proteinuria will be formed. 2. Hypoproteinemia: a large amount of protein is lost in the urine, at the same time, protein catabolism increases, resulting in hypoproteinemia. The mucosal edema of the digestive tract leads to loss of appetite and insufficient protein intake, which may further aggravate hypoproteinemia. Long-term massive protein loss may lead to malnutrition and growth retardation. 3. Edema: Hypoproteinemia causes a decrease in plasma colloid osmotic pressure, and water enters the tissue interstitial space from the vascular cavity, which is an important cause of edema. In addition, some patients have insufficient effective circulating blood volume, activation of renin-angiotensin-aldosterone system and increased secretion of antidiuretic hormone, which can increase sodium reabsorption in renal tubules and further aggravate edema. Patients with membranoproliferative glomerulonephritis are advised to go to regular hospitals for timely consultation and standardized treatment under the guidance of doctors.