There is no absolute fastest treatment for thickened toenails, and general and causal treatments are mostly used. 1. General treatment: When there is obvious thickening of the toenails, gray, under the guidance of the doctor, you can use a knife or nail clippers to scrape the surface of the sick nails. 2. Causal treatment (1) Pustular psoriasis: patients can use glucocorticoid (budesonide), vitamin D3 derivatives, retinoic acid and other medicines under the guidance of doctors for treatment. Physical therapy, such as photochemotherapy, is also available. (2) Congenital Thick Nail Syndrome: Nail matrix and nail bed scraping can be used; local keratinized lesions can be treated with lactic acid lotion, salicylic acid, etc. (3) Tinea pedis: localized topical antifungal drugs, such as miconazole, econazole, naftifine, etc., or oral terbinafine, itraconazole, etc., can be used for systemic treatment. The above drugs are recommended to be used under the guidance of a doctor. There are many causes of thickened toenails, so it is recommended to go to the hospital and get timely treatment.