The main cause of high aminotransferase and glutamic oxalacetic aminotransferase is due to several reasons. 1. The main cause is liver damage, which can lead to elevated aminotransferases, such as viral hepatitis, hepatitis B, hepatitis A, hepatitis C, which can lead to different degrees of elevated aminotransferases, or cirrhosis of the liver or liver cancer. 2. 3.Expressed in the heart or skeletal muscle. Elevated glutathione and glutamic oxalacetic aminotransferase can be seen in myocarditis, acute myocardial infarction, heart failure, or skeletal muscle disease.