Peritoneal dialysis is easy to lead to infection, and the prevention and treatment of infection is mainly to strengthen nursing care and so on. Peritoneal dialysis fluid change place should be dry, the operation process is strictly in accordance with the aseptic requirements of treatment, diligent change of clothes, etc.; skin localization should be closely observed, keep the local clean, dry, 4~8 weeks after the wound healing, feasible shower, before and after the daily dialysis should be carried out before and after the local disinfection. After infection occurs, bacterial culture and drug sensitivity test of secretion should be taken in time; local dressing change; systemic antibiotic treatment should be carried out and adjusted in time according to drug sensitivity. Peritoneal dialysis is very susceptible to infections, strict adherence to aseptic operation, timely detection and active treatment is the key to the success of peritoneal dialysis, should strictly follow the guidance of professional doctors.