The white rice-like hard spots on the soles of the feet are considered to be plantar warts, fossa keratolysis, palmoplantar pustulosis, and can be treated with topical medications and physical therapy. 1. Metatarsal warts: related to viral infection, if there are no obvious symptoms, and relatively small, may disappear on their own. If the plantar warts are big, you can use topical medication to treat them, such as retinoic acid ointment, salicylic acid solution, etc., but you must insist on using it. Some of the patients are not good enough to use external drugs, can take physical therapy, such as cryotherapy, laser treatment. 2. Vulval keratolysis: mainly caused by rod-shaped bacillus infection, can be applied locally antibiotic ointment, such as fusidic acid cream, erythromycin ointment and so on. 3. Palmoplantar pustulosis: may be related to stress, smoking and other factors, can be used locally glucocorticoid drugs, such as mometasone furoate cream, Dinaid cream, and with oral retinoic acid medication, such as Avicenna. The white rice-like hard spots on the soles of the feet should go to the dermatology department of the hospital in time to find out the cause of the problem and then take targeted treatment. If you need to use medication, you must follow the doctor’s instructions to use, do not self-medication, so as not to cause adverse effects.