Jaundice in preterm infants is also divided into pathological and physiological jaundice. Physiological jaundice is generally due to poor liver metabolism and excessive blood cell destruction in preterm infants, so it is more likely to make the bilirubin value too high and last longer, basically about 21 days before it can completely subside. 2, because the development of various physiological functions of preterm infants is not complete, so compared to full-term infants are more prone to pathological jaundice, pathological jaundice bilirubin value is higher, while the duration is longer, sometimes about 2-3 months to be able to subside, if the bilirubin value is too high, we also need to give phototherapy at the same time, with the promotion of bilirubin metabolism drugs, such as gardenia yellow granules, drink more water to promote If the jaundice is caused by a viral infection, antiviral medication is needed to reduce the jaundice. Because the blood-brain barrier is not fully developed in preterm infants, they are more sensitive to elevated bilirubin, and bilirubin values exceeding 15 mg/dl may lead to bilirubin encephalopathy, so doctors and parents should pay more attention to hyperbilirubinemia in preterm infants, and timely phototherapy to reduce bilirubin to a safe range, and for those with poor phototherapy results, consider blood exchange therapy, otherwise it may easily develop into bilirubin encephalopathy.