Expired ibuprofen should not be taken. Ibuprofen is indicated for antipyretic, analgesic and anti-inflammatory purposes, and has the effect of relieving chronic arthritis, tenosynovitis, bursitis, toothache, primary dysmenorrhea and headache. It also has an antipyretic effect on fever. If the drug is outdated, the efficacy will be reduced or even disappear, which may delay the condition and increase the risk of adverse reactions, such as nausea, vomiting, blood in the stools and itching of the skin. Expired drugs not only have reduced efficacy, but can also lead to overdose and toxic reactions if the dose is increased. For example, an overdose of expired ibuprofen can lead to adverse symptoms such as vomiting, headache, drowsiness and low blood pressure. Ibuprofen is an NSAID and should be contraindicated in asthmatics who are allergic to other NSAIDs and aspirin. The appearance of expired ibuprofen may not have changed significantly, but the composition and quality of the drug has changed. Not only is it ineffective, but it can also deteriorate and the active ingredients can be transformed. Therefore, when storing medicines at home, it is necessary to take care of regular cleaning of expired medicines to avoid adverse reactions caused by misuse. Medicines need to be used under the guidance of a doctor.