Diosmin tablets and irbesartan hydrochlorothiazide can be taken together. Diosmin can improve the permeability of lymph and blood vessels, reduce local edema, clinically can be used in the treatment of patients with lower limb edema and hemorrhoids, reduce the symptoms of edema and hemorrhoids, but people with poor gastrointestinal function or allergies should be cautious. Irbesartan hydrochlorothiazide belongs to the compound preparation, the main indication is hypertension, especially suitable for patients with hypertension accompanied by edema, there can be dizziness, nausea, tinnitus, electrolyte disorders and other multi-system adverse reactions, but the incidence is low. It is contraindicated in pregnant and lactating women and in those with severe hepatic or renal insufficiency, and in the presence of hypokalemia/hypercalcemia. There are no contraindications to the combination of Diosmin and Irbesartan Hydrochlorothiazide, the two drugs can be used together, especially suitable for the treatment of hypertension with lower limb edema and hemorrhoids, in lowering blood pressure while being able to improve the symptoms of edema and hemorrhoids. Diosmin and Irbesartan Hydrochlorothiazide should be taken at the same time should follow the medical advice, under the guidance of the physician, choose the appropriate indications and the dose of the drug.