1.Adverse effects of isoniazid: (1) Peripheral neuritis (2) Effects on the central nervous system (3) Toxic effects on the liver (4) Possible optic neuritis, muscle twitching, urinary difficulties, granulocytopenia, drug rash, gynecomastia, sinus tachycardia, etc. 2.Adverse reactions of rifampicin: (1) liver damage (2) gastrointestinal reactions (3) skin syndrome (4) flu-like syndrome (5) respiratory reactions (6) renal failure, thrombocytopenia, and teratogenic effects, etc. 3, adverse reactions of streptomycin: (1) allergic reactions (2) acute toxic reactions (3) chronic toxic reactions: a, damage to the eighth to cranial nerve b, local irritation c, bone marrow suppression d, other. 4.Adverse reactions of pyrazinamide: (1) liver damage (2) arthralgia (3) gastrointestinal reactions (4) can also cause hyperuricemia, drug fever, rash and photosensitivity, etc. 5.Adverse effects of ethambutol: (1) postbulbar optic neuritis, vision loss and color discrimination difficulties (2) other symptoms such as gastrointestinal symptoms, headache, angioneurotic edema, peripheral neuritis, arthralgia, abnormal liver function, granulocytopenia.